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Frances J D Smith Selected Research

Juvenile Epithelial of Meesmann Corneal Dystrophy

3/2016Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy.
1/2013Allele-specific siRNA silencing for the common keratin 12 founder mutation in Meesmann epithelial corneal dystrophy.
1/2011Development of allele-specific therapeutic siRNA in Meesmann epithelial corneal dystrophy.

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Frances J D Smith Research Topics

Disease

18Pachyonychia Congenita (Jadassohn-Lewandowsky Syndrome)
12/2017 - 10/2006
6Atopic Dermatitis (Atopic Eczema)
05/2009 - 04/2006
5Ichthyosis Vulgaris (Dominant Ichthyosis Vulgaris)
05/2009 - 03/2006
4Inborn Genetic Diseases (Disease, Hereditary)
09/2008 - 10/2002
3Juvenile Epithelial of Meesmann Corneal Dystrophy
03/2016 - 01/2011
3Skin Diseases (Skin Disease)
06/2015 - 06/2012
3Epidermolysis Bullosa Simplex (Epidermolysis Bullosa Herpetiformis Dowling Meara)
01/2014 - 01/2004
2Pain (Aches)
09/2017 - 06/2012
2Hypersensitivity (Allergy)
11/2015 - 10/2013
2Dermatitis
11/2015 - 10/2013
2Poikiloderma of Kindler
01/2004 - 07/2003
2Ectodermal Dysplasia (Aplasia Cutis Congenita)
11/2003 - 03/2002
1Skin Fragility-Woolly Hair Syndrome
01/2018
1Hereditary Corneal Dystrophies
03/2016
1Corneal Opacity
03/2016
1Wasting Syndrome (Wasting Disease)
11/2015
1Neoplasms (Cancer)
06/2015
1Keratosis
03/2015
1Cheilitis
03/2015
1Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris)
12/2013
1Alopecia (Baldness)
07/2012
1Epidermolytic Palmoplantar Keratoderma
06/2012
1Eye Diseases (Eye Disease)
01/2011
1Hyperkeratosis of the palms and soles and esophageal papillomas
02/2010
1Pancreatic Neoplasms (Pancreatic Cancer)
05/2009
1X-Linked Ichthyosis (Ichthyosis, X Linked)
12/2007
1Asthma (Bronchial Asthma)
07/2007
1Eczema
05/2007
1Ichthyosis (Xeroderma)
08/2006
1Burnett Schwartz Berberian syndrome
08/2006
1Cysts
10/2005
1Malformed Nails (Pachyonychia)
04/2004
1Photosensitivity Disorders (Photodermatitis)
01/2004
1Laryngo onycho cutaneous syndrome
09/2003
1Junctional Epidermolysis Bullosa (Epidermolysis Bullosa Letalis)
09/2003

Drug/Important Bio-Agent (IBA)

19Keratins (Keratin)IBA
09/2017 - 10/2002
9Filaggrin ProteinsIBA
05/2009 - 03/2006
7Small Interfering RNA (siRNA)IBA
01/2013 - 10/2006
5Keratin-17 (Keratin 17)IBA
07/2017 - 04/2004
3Keratin-6 (Keratin 6A)IBA
12/2017 - 03/2008
3Proteins (Proteins, Gene)FDA Link
03/2016 - 07/2003
3NucleotidesIBA
05/2011 - 10/2006
2Desmoplakins (Desmoplakin)IBA
01/2018 - 11/2015
2RetinoidsIBA
09/2017 - 06/2012
2Keratin-12 (Keratin 12)IBA
03/2016 - 01/2013
2Desmoglein 1IBA
11/2015 - 10/2013
2Connexin 30IBA
11/2003 - 03/2002
1calpastatinIBA
03/2015
1PlectinIBA
01/2014
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
12/2013
1CytokinesIBA
10/2013
1Keratin-5 (Keratin 5)IBA
10/2011
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
05/2011
1Messenger RNA (mRNA)IBA
05/2009
1laminin alpha 3IBA
09/2003
1Protein Isoforms (Isoforms)IBA
09/2003

Therapy/Procedure

5Therapeutics
03/2016 - 03/2008
1Slit Lamp
03/2016
1RNAi Therapeutics
06/2012
1Intravenous Injections
05/2009